2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
SR 0987
CAS: 303126-97-8
Molecular Formula: C16H10ClF6NO2
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide - Names and Identifiers
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide - Physico-chemical Properties
| Molecular Formula | C16H10ClF6NO2 |
| Molar Mass | 397.7 |
| Density | 1.525±0.06 g/cm3(Predicted) |
| Boling Point | 378.8±42.0 °C(Predicted) |
| Solubility | DMSO : 150 mg/mL (377.17 mM) |
| Appearance | solid |
| Color | White |
| pKa | 9.22±0.15(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| Use | SR0987 is an analog of SR1078 and an agonist of RORγt, with an EC50 value of 800 nM. SR0987 can up-regulate the expression of IL17 and inhibit the expression of PD-1. |
| In vitro study | SR0987 clearly shows a concentration dependent induction of reporter gene expression with an EC 50 of ~800nM. SR0987 treatment results in a statistically significant reduction of the surface expression of PD-1 whereas desmostrol treatment shows no effect. Treatment with SR0987 and or desmosterol results in a trend towards increased IL17 production. |
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.514 ml | 12.572 ml | 25.145 ml |
| 5 mM | 0.503 ml | 2.514 ml | 5.029 ml |
| 10 mM | 0.251 ml | 1.257 ml | 2.514 ml |
| 5 mM | 0.05 ml | 0.251 ml | 0.503 ml |
Last Update：2024-01-02 23:10:35
2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide - Reference Information
| biological activity | SR 0987 is an analog of SR 1078, it is an agonist of T cell-specific ROR gamma (ROR gamma t) with an EC50 value of 800 nM. SR 0987 can inhibit PD-1, produce IL17, and has the potential to treat cancer. |
| Target | Value |
| PD-1 () | |
| IL17 () | |
| RORγt (Cell-free assay) | 800 nM(EC50) |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: SR 0987 Visit Supplier Webpage Request for quotationCAS: 303126-97-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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